Category: News

Convergence of Inflammatory Pathways in Allergic Asthma and Sickle Cell Disease

Authors Amali E Samarasinghe, Jason W Rosch  The underlying pathologies of sickle cell disease and asthma share many characteristics in terms of respiratory inflammation. The principal mechanisms of pulmonary inflammation are largely distinct, but activation of common pathways downstream of the initial inflammatory triggers may lead to exacerbation of both disease states. The altered inflammatory …

Ketamine In Acute and Chronic Pain Management

Authors Vwaire J. Orhurhu , Jacob S. Roberts, Steven P. Cohen Acute and chronic pain remain important health problems both in the United States and worldwide. With the rise in the prevalence of many chronic degenerative diseases across the globe, the distribution and absolute numbers of persons experiencing acute and chronic pain have continued to …

American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support.

BACKGROUND: Red cell transfusions remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. Guidance for specific indications and administration of transfusion, as well as screening, prevention, and management of alloimmunization, delayed hemolytic transfusion reactions (DHTRs), and iron overload may improve outcomes. OBJECTIVE: Our objective was to develop …

Guide to Sickle Cell and Employment

“A team at De Montfort University (Professor Simon Dyson and Dr Maria Berghs) in the UK has recently completed a project looking at sickle cell, work and employment. The project has produced a Guide to Sickle Cell and Employment and produced a web-site with some further resources at http://sicklecellwork.dmu.ac.uk. …

Not being heard: barriers to high quality unplanned hospital care during young people’s transition to adult services – evidence from ‘this sickle cell life’ research.

BACKGROUND: Young people’s experiences of healthcare as they move into adult services can have a major impact on their health, and the transition period for young people with sickle cell disease (SCD) needs improvement. In this study, we explore how young people with SCD experience healthcare during this period of transition. METHODS: We conducted a …